GLIPRIDE is indicated as an adjunct to diet, exercise and weight loss, to lower the blood glucose in patients with non-insulin-dependent (type 2) diabetes mellitus.
Use of Oral Hypoglycemic Agents (OHAs) should only be initiated when the blood glucose management is not achieved with diet restrictions and exercise. In no way should GLIPRIDE is suggested to be used as a substitute for diet control.
Initial dose adjustment
- The initial dose of GLIPRIDE is one 1 mg tablet once daily. If good metabolic control achieved within the first week of treatment (as determined by blood and urine glucose), the daily dose of one 1 mg tablet should be continued as maintenance therapy.
- If metabolic control is unsatisfactory after 1 – 2 weeks of treatment, increase the daily dose in increments of 1 mg at 1 to 2 week intervals, until satisfactory metabolic control is achieved. Most patients will achieve optimum control at doses of 1 mg to 4 mg once daily. Only in exceptional cases will doses of more than 4 mg glimepiride per day give better results.
- Normally, a single daily dose will maintain good blood glucose control for 24 hours.
Secondary dosage adjustment
- GLIPRIDE requirements may fall as treatment proceeds because an improvement in diabetes control results in greater insulin sensitivity. To avoid hypoglycaemia, timely dose reduction or cessation of therapy should be considered.
- Correction of GLIPRIDE dosage must also be considered whenever the patient’s weight or life-style changes or other factors arise which affect glycaemic control.
- Secondary failures should be treated by discontinuing GLIPRIDE and starting insulin.
- Hypersensitivity to glimepiride, other sulfonylureas, other sulfonamides or any excipient.
- Severe impairment of renal function (CrCl <30 mL/min).
- Dialysis patients.
- Severe hepatic dysfunction.
- Pregnancy
- Lactation
- Hypoglycemia
- Hypersensitivity Reactions
- Hemolytic Anemia
- Risk of Cardiovascular Mortality
- Macrovascular Outcomes
- Hypoglycemia
- Weight gain
- Allergic Reactions
Store between 15 and 30°C, away from heat, moisture and direct light.
GLIPRIDE 1 mg: 10×10’s
GLIPRIDE 2 mg: 10×10’s
GLIPRIDE 3 mg: 10×10’s
GLIPRIDE 4 mg: 10×10’s
